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At 0.5 mg per week, a 5% error is 0.025 mg, still clinically insignificant, but a 50% error (which is easy to make at very low volumes) means you are taking 0.25 mg or 0.75 mg instead of 0.5 mg

Diphenhydramine withdrawal is severe and takes 7 to 14 days to finish

Berndt-Zipfel C, Michelson G, Dworak M, et al

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